Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo.

ABSTRACT: Cocaine is a highly addictive psychostimulant that acts through competitive inhibition of the dopamine transporter. In order to fully understand the region specific neuropathology of cocaine abuse and addiction, it is unequivocally necessary to develop cocaine sensing technology capable of directly measuring real-time cocaine transient events local to different brain regions throughout the pharmacokinetic time course of exposure. We have developed an electrochemical aptamer-based in vivo cocaine sensor on a silicon based neural recording probe platform capable of directly measuring cocaine from discrete brain locations using square wave voltammetry (SWV). The sensitivity of the sensor for cocaine follows a modified exponential Langmuir model relationship and complete aptamer-target

SUBMITTER: Taylor IM 

PROVIDER: S-EPMC5512874 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature