Short DNA sequence patterns accurately identify broadly active human enhancers.

ABSTRACT:

Background

Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers' activity patterns: some enhancers drive expression in a single cellular context, while others are active across many. Sequence characteristics, such as transcription factor (TF) binding motifs, influence the activity patterns of regulatory sequences; however, the regulatory logic through which specific sequences drive enhancer activity patterns is poorly understood. Recent analysis of Drosophila enhancers suggested that short dinucleotide repeat motifs (DRMs) are general enhancer sequence features that drive broad regulatory activity. However, it is not known whether the regulatory role of DRMs is conserved across species.

Results

We performed a compr

SUBMITTER: Colbran LL 

PROVIDER: S-EPMC5512948 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature