Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants.

ABSTRACT:

Background

Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact upon the validity of data for benchmarking purposes.

Method

Data from all VLGA or VLBW infants admitted in the 3 Networks between 2008 and 2011 were used. Two-thirds of each network cohort was randomly selected to develop prediction models for mortality and composite adverse outcome (CAO: mortality or cerebral injuries, chronic lung disease, severe retinopathy or necrotizing enterocolitis) and the remaining for internal validation. Areas under the ROC curves (AUC) of the models were compared.

Results

VLBW cohort (24,335 infants) had twice more SGA infan

SUBMITTER: Koller-Smith LI 

PROVIDER: S-EPMC5512978 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature