Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population.

ABSTRACT:

Background

Schizophrenia (SCZ) is a common mental disorder with high heritability, and genetic factors play a major role in the pathogenesis. Recent researches indicated that the CACNA1I involved in calcium channels probably affect the potential pathogenesis of SCZ.

Results

In this study, we attempted to investigate whether the CACNA1I gene contributes the risk to SCZ in the Uighur Chinese population, and performed a case-control study involving 985 patient samples and 1218 normal controls to analyze nine SNPs within the CACNA1I gene. Among these sites, six SNPs were significantly associated with SCZ in the allele distribution: rs132575 (adjusted P_allele  = 0.039, OR = 1.159), rs713860 (adjusted P_allele  

SUBMITTER: Xu W 

PROVIDER: S-EPMC5513035 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature