MCTBI: a web server for predicting metal ion effects in RNA structures.

ABSTRACT: Metal ions play critical roles in RNA structure and function. However, web servers and software packages for predicting ion effects in RNA structures are notably scarce. Furthermore, the existing web servers and software packages mainly neglect ion correlation and fluctuation effects, which are potentially important for RNAs. We here report a new web server, the MCTBI server (http://rna.physics.missouri.edu/MCTBI), for the prediction of ion effects for RNA structures. This server is based on the recently developed MCTBI, a model that can account for ion correlation and fluctuation effects for nucleic acid structures and can provide improved predictions for the effects of metal ions, especially for multivalent ions such as Mg²⁺ effects, as shown by extensive theory-experiment tes

SUBMITTER: Sun LZ 

PROVIDER: S-EPMC5513060 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature