A Cooperative Copper Metal-Organic Framework-Hydrogel System Improves Wound Healing in Diabetes.

ABSTRACT: Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes. Herein we set out to assess whether copper metal organic framework nanoparticles (HKUST-1 NPs) embedded within an antioxidant thermoresponsive citrate-based hydrogel would decrease copper ion toxicity and accelerate wound healing in diabetic mice. HKUST-1 and poly

SUBMITTER: Xiao J 

PROVIDER: S-EPMC5513192 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature