Potential and active functions in the gut microbiota of a healthy human cohort.

ABSTRACT:

Background

The study of the gut microbiota (GM) is rapidly moving towards its functional characterization by means of shotgun meta-omics. In this context, there is still no consensus on which microbial functions are consistently and constitutively expressed in the human gut in physiological conditions. Here, we selected a cohort of 15 healthy subjects from a native and highly monitored Sardinian population and analyzed their GMs using shotgun metaproteomics, with the aim of investigating GM functions actually expressed in a healthy human population. In addition, shotgun metagenomics was employed to reveal GM functional potential and to compare metagenome and metaproteome profiles in a combined taxonomic and functional fashion.

Results

Metagenomic and metaproteomic data conce

SUBMITTER: Tanca A 

PROVIDER: S-EPMC5513205 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature