Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities.

ABSTRACT:

Background

Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malaria transmission.

Methods

P. falciparum at delivery was assessed by microscopy, quantitative PCR (qPCR) and placental histology in 946 HIV-uninfected and 768 HIV-infected pregnant women from Benin, Gabon, Kenya and Mozambique. Resistance was defined by the proportion of submicroscopic infections and the levels of anti-parasite antibodies quantified by Luminex, and tolerance by the relationship of pregnancy outcomes with parasite densities at delivery.

Results

SUBMITTER: Ndam NT 

PROVIDER: S-EPMC5513247 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature