A novel isoform of IL-33 revealed by screening for transposable element promoted genes in human colorectal cancer.

ABSTRACT: Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes. These sequences contain multiple regulatory motifs and hence are capable of influencing expression of host genes. TEs are known to be released from epigenetic repression and can become transcriptionally active in cancer. Such activation could also lead to lineage-inappropriate activation of oncogenes, as previously described in lymphomas. However, there are few reports of this mechanism occurring in non-blood cancers. Here, we re-analyzed whole transcriptome data from a large cohort of patients with colon cancer, compared to matched normal colon control samples, to detect genes or transcripts ectopically expressed through activation of TE promoters. Among many such transcripts, we identified six where the af

SUBMITTER: Lock FE 

PROVIDER: S-EPMC5513427 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature