Elevated interleukin-10: a new cause of dyslipidemia leading to severe HDL deficiency.

ABSTRACT:

Background

Low high-density lipoprotein cholesterol (HDL-C) is a risk factor for coronary artery disease. Investigating mechanisms underlying acquired severe HDL deficiency in noncritically ill patients ("disappearing HDL syndrome") could provide new insights into HDL metabolism.

Objective

To determine the cause of low HDL-C in patients with severe acquired HDL deficiency.

Methods and results

Patients with intravascular large B-cell lymphoma (n = 2), diffuse large B-cell lymphoma (n = 1), and autoimmune lymphoproliferative syndrome (n = 1) presenting with markedly decreased HDL-C, low low-density lipoprotein cholesterol (LDL-C), and elevated triglycerides were identified. The abnormal lipoprotein profile returned to normal after therapy in all 4 patients. All patients

SUBMITTER: Moraitis AG 

PROVIDER: S-EPMC5513489 | biostudies-literature | 2015 Jan-Feb

REPOSITORIES: biostudies-literature