Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress.

ABSTRACT: Despite substantial evidence for the central role of hemodynamic shear stress in the functional integrity of vascular endothelial cells, hemodynamic and molecular regulation of the endocardial endothelium lining the heart chambers remains understudied. We propose that regional differences in intracardiac hemodynamics influence differential endocardial gene expression leading to phenotypic heterogeneity of this cell layer. Measurement of intracardiac hemodynamics was performed using 4-dimensional flow MRI in healthy humans (n=8) and pigs (n=5). Local wall shear stress (WSS) and oscillatory shear indices (OSI) were calculated in three distinct regions of the LV - base, mid-ventricle (midV), and apex. In both the humans and pigs, WSS values were significantly lower in the apex and midV relati

SUBMITTER: McCormick ME 

PROVIDER: S-EPMC5513694 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature