Cord-Blood Transplantation in Patients with Minimal Residual Disease.

ABSTRACT:

Background

The majority of patients in need of a hematopoietic-cell transplant do not have a matched related donor. Data are needed to inform the choice among various alternative donor-cell sources.

Methods

In this retrospective analysis, we compared outcomes in 582 consecutive patients with acute leukemia or the myelodysplastic syndrome who received a first myeloablative hematopoietic-cell transplant from an unrelated cord-blood donor (140 patients), an HLA-matched unrelated donor (344), or an HLA-mismatched unrelated donor (98).

Results

The relative risks of death and relapse between the cord-blood group and the two other unrelated-donor groups appeared to vary according to the presence of minimal residual disease status before transplantation. Among patients with m

SUBMITTER: Milano F 

PROVIDER: S-EPMC5513721 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature