Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity.

ABSTRACT:

Objective

To evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls.

Methods

A total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 16 without IR) were evaluated using a high spatial resolution arterial spin labeling MRI technique at rest and during mild hypercapnia. We analyzed group differences in CVR in cerebral cortex and ascertained the relationships between CVR, IR, and body mass index (BMI).

Results

Obese/overweight participants with and without IR had significantly lower CVR to hypercapnia than lean controls after controlling for age, sex, and the presence of hypertension (F

SUBMITTER: Frosch OH 

PROVIDER: S-EPMC5513815 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature