A comprehensive insight into the clinicopathologic significance of miR-144-3p in hepatocellular carcinoma.

ABSTRACT:

Background

Studies which focused on the character of miR-144-3p in hepatocellular carcinoma (HCC) are limited. This study aimed to explore the expression, clinical significance and the potential targets of miR-144-3p in HCC.

Methods

The Cancer Genome Atlas (TCGA) and a cohort of 95 cases of HCC were applied to investigate aberrant miR-144-3p expression in HCC. A meta-analysis was performed to accumulate data on miR-144-3p expression in HCC based on TCGA, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Gene Expression Omnibus (GEO). Additionally, the potential regulatory mechanisms of miR-144-3p in HCC were explored by bioinformatics.

Results

MiR-144-3p expression was downregulated distinctly in HCC compared to para-HCC tissue both in TCGA da

SUBMITTER: Liang HW 

PROVIDER: S-EPMC5513884 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature