Feasibility of 4D perfusion CT imaging for the assessment of liver treatment response following SBRT and sorafenib.

ABSTRACT:

Objectives

To evaluate the feasibility of 4-dimensional perfusion computed tomography (CT) as an imaging biomarker for patients with hepatocellular carcinoma and metastatic liver disease.

Methods and materials

Patients underwent volumetric dynamic contrast-enhanced CT on a 320-slice scanner before and during stereotactic body radiation therapy and sorafenib, and at 1 and 3 months after treatment. Quiet free breathing was used in the CT acquisition and multiple techniques (rigid or deformable registration as well as outlier removal) were applied to account for residual liver motion. Kinetic modeling was performed on a voxel-by-voxel basis in the gross tumor volume and normal liver resulting in 3-dimensional parameter maps of blood perfusion, capillary permeability, blood volu

SUBMITTER: Coolens C 

PROVIDER: S-EPMC5514015 | biostudies-literature | 2016 Jul-Sep

REPOSITORIES: biostudies-literature