FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling.

ABSTRACT:

Purpose

Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector.

Methods and materials

BALB/c mice with telogen or plucking-induced anagen HFs were exposed to total body irradiation with γ-rays at 4 to 12 Gy after intraperitoneal treatment with FGF18 or an FGF receptor inhibitor. A time course analysis was performed histologically and hair growth was observed 14

SUBMITTER: Kawano M 

PROVIDER: S-EPMC5514016 | biostudies-literature | 2016 Jul-Sep

REPOSITORIES: biostudies-literature