Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone.

ABSTRACT: Emergence of epidemic clones and antibiotic resistance development compromises the management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections. Whole genome sequencing (WGS) was used to decipher the phylogeny, interpatient dissemination, WGS mutator genotypes (mutome) and resistome of a widespread clone (CC274), in isolates from two highly-distant countries, Australia and Spain, covering an 18-year period. The coexistence of two divergent CC274 clonal lineages was revealed, but without evident geographical barrier; phylogenetic reconstructions and mutational resistome demonstrated the interpatient transmission of mutators. The extraordinary capacity of P. aeruginosa to develop resistance was evidenced by the emergence of mutations in >100 genes related to antib

SUBMITTER: Lopez-Causape C 

PROVIDER: S-EPMC5514035 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature