Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.

ABSTRACT: Tissue microenvironments formed by extracellular matrix networks play an important role in regulating tissue structure and function. Extracellular microfibrillar networks composed of fibrillins and their associated ligands such as LTBPs, fibulins, and EMILINs are of particular interest in this regard since they provide a specialized cellular microenvironment guiding proper morphology and functional behavior of specialized cell types. To understand how cellular microenvironments composed of intricate microfibrillar networks influence cell fate decisions in a contextual manner, more information about the spatiotemporal localization, deposition, and function of their components is required. By employing confocal immunofluorescence and electron microscopy we investigated the localization and e

SUBMITTER: Schiavinato A 

PROVIDER: S-EPMC5514116 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature