Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer.

ABSTRACT: The vast majority of cancer-related deaths are due to metastatic disease, whereby primary tumor cells disseminate and colonize distal sites within the body. Triple negative breast cancer typically displays aberrant Wnt signaling, lacks effective targeted therapies, and compared with other breast cancer subtypes, is more likely to recur and metastasize. We developed a Wnt-driven lung metastasis model of triple negative breast cancer (metM-Wnt^lung) through serial passaging of our previously described, nonmetastatic, claudin-low M-Wnt cell line. metM-Wnt^lung cells displayed characteristics of epithelial-to-mesenchymal transition (e.g., increased invasiveness) with some re-epithealization (e.g., increased adhesion, tight colony formation, increased E-cadherin expre

SUBMITTER: O'Flanagan CH 

PROVIDER: S-EPMC5514148 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature