Limited short-term effect of palliative radiation therapy on quantitative computed tomography-derived bone mineral density in femora with metastases.

ABSTRACT:

Purpose

The aim of this study was to determine the effect of single fraction (SF) and multiple fraction (MF) radiation therapy (RT) on bone mineral density (BMD) in patients with cancer and bone metastases in the proximal femur. We studied this effect in the radiation field and within metastatic lesions, and differentiated between lytic, blastic, and mixed lesions.

Methods and materials

This prospective cohort study comprised 42 patients with painful bone metastases, including 47 irradiated femora with 52 metastatic lesions in the proximal femur. Patients received either 8 Gy SF or 20 to 24 Gy in 5 to 6 fractions (MF). Quantitative computed tomography scans were obtained before RT and 4 and 10 weeks after the initial scan. Patients who received MF additionally underwent quan

SUBMITTER: Eggermont F 

PROVIDER: S-EPMC5514233 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature