Functional image guided radiation therapy planning in volumetric modulated arc therapy for patients with malignant pleural mesothelioma.

ABSTRACT:

Purpose

To investigate the incorporation of functional lung image-derived low-attenuation area (LAA) based on 4-dimensional computed tomography (4D-CT) in volumetric modulated arc therapy (VMAT) planning for patients with malignant pleural mesothelioma (MPM) after extrapleural pneumonectomy.

Methods and materials

Twelve patients with MPM after extrapleural pneumonectomy were included. The primarily affected side was the right in 6 patients and the left in 6 patients. LAA was generated from 4D-CT data according to CT values with a threshold of less than -860 Hounsfield units (HU). Functional lung image was defined as the area where LAA was excluded from contralateral lung image. Two radiation therapy plans were designed: (1) Plan C, conventional VMAT and (2) Plan F, functiona

SUBMITTER: Doi Y 

PROVIDER: S-EPMC5514243 | biostudies-literature | 2017 Apr-Jun

REPOSITORIES: biostudies-literature