A novel treatment for tinnitus and tinnitus-related cognitive difficulties using computer-based cognitive training and D-cycloserine.

ABSTRACT:

Importance

Tinnitus affects more than 40 million people in the Unites States, and cognitive difficulties are among the most commonly associated symptoms.

Objective

To test the feasibility and preliminarily the effectiveness of using a putative neuroplasticity-enhancing drug, D-cycloserine, to facilitate a computer-assisted CT program for improving tinnitus bother and related cognitive difficulties.

Design, setting, and participants

Double-blind, randomized clinical trial at an outpatient academic medical center of 34 participants aged 35 to 65 years with subjective, unilateral or bilateral, nonpulsatile tinnitus of at least 6 months' duration.

Interventions

Five weeks of twice-weekly computer-based CT with either 250 mg D-cycloserine or placebo orally prior to

SUBMITTER: Krings JG 

PROVIDER: S-EPMC5514293 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature