The role of postoperative neurocognitive dysfunction on quality of life for postmenopausal women 6 months after cardiac surgery.

ABSTRACT:

Background

Women are prone to neurological complications after cardiac surgery. We have previously reported that treatment perioperatively with the neuroprotectant steroid 17beta-estradiol did not improve neurocognitive end-points 4 to 6 wk after surgery for elderly women. In this study, we evaluated the influence of early postoperative neurocognitive dysfunction on quality of life in postmenopausal women undergoing cardiac surgery and whether it is impacted by perioperative 17beta-estradiol treatment.

Methods

One hundred seventy-four postmenopausal women randomly received 17beta-estradiol or placebo in a double-blind manner beginning the day before surgery and continued until the fifth postoperative day. The patients underwent psychometric testing using a standard battery b

SUBMITTER: Hogue CW 

PROVIDER: S-EPMC5514369 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature