Association study to evaluate TFPI gene in CAD in Han Chinese.

ABSTRACT:

Background

Tissue factor pathway inhibitor (TFPI) is the main physiological inhibitor of TF-induced blood coagulation process, and may play essential roles in the pathogenesis of major adverse cardiac events. This study was designed to determine whether the variation of TFPI was related with coronary artery disease (CAD) in the Han Chinese populations.

Methods

A total of 1271 patients with coronary atherosclerosis and 1287 normal individuals from northern China were enrolled in the present study. Four tagging single-nucleotide polymorphisms (SNPs) (rs7586970, rs6434222, rs10153820 and rs8176528) from TFPI were selected and genotyped by direct sequencing. And the genotypes of the above SNPs were determined in all these participants.

Results

In the populations from Beij

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC5514508 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature