Variant Ranker: a web-tool to rank genomic data according to functional significance.

ABSTRACT:

Background

The increasing volume and complexity of high-throughput genomic data make analysis and prioritization of variants difficult for researchers with limited bioinformatics skills. Variant Ranker allows researchers to rank identified variants and determine the most confident variants for experimental validation.

Results

We describe Variant Ranker, a user-friendly simple web-based tool for ranking, filtering and annotation of coding and non-coding variants. Variant Ranker facilitates the identification of causal variants based on novelty, effect and annotation information. The algorithm implements and aggregates multiple prediction algorithm scores, conservation scores, allelic frequencies, clinical information and additional open-source annotations using accessible dat

SUBMITTER: Alexander J 

PROVIDER: S-EPMC5514526 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature