The Lectin Chaperone Calnexin Is Involved in the Endoplasmic Reticulum Stress Response by Regulating Ca²⁺ Homeostasis in Aspergillus nidulans.

ABSTRACT: The Ca²⁺-mediated signaling pathway is crucial for environmental adaptation in fungi. Here we show that calnexin, a molecular chaperone located in the endoplasmic reticulum (ER), plays an important role in regulating the cytosolic free calcium concentration ([Ca²⁺]_c) in Aspergillus nidulans Inactivation of calnexin (ClxA) in A. nidulans caused severe defects in hyphal growth and conidiation under ER stress caused by the ER stress-inducing agent dithiothreitol (DTT) or high temperature. Importantly, defects in the ΔclxA mutant were restored by the addition of extracellular calcium. Furthermore, the CchA/MidA complex (the high-affinity Ca²⁺ channels), calcineurin (calcium/calmodulin-dependent protein phosphatase), and PmrA (sec

SUBMITTER: Zhang S 

PROVIDER: S-EPMC5514668 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature