Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes.

ABSTRACT:

Aims/hypotheses

In adults, type 2 diabetes and obesity have been associated with structural brain changes, even in the absence of dementia. Some evidence suggested similar changes in adolescents with type 2 diabetes but comparisons with a non-obese control group have been lacking. The aim of the current study was to examine differences in microstructure of gray and white matter between adolescents with type 2 diabetes, obese adolescents and healthy weight adolescents.

Methods

Magnetic resonance imaging data were collected from 15 adolescents with type 2 diabetes, 21 obese adolescents and 22 healthy weight controls. Volumetric differences in the gray matter between the three groups were examined using voxel based morphology, while tract based spatial statistics was used to ex

SUBMITTER: Nouwen A 

PROVIDER: S-EPMC5514690 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature