Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.

ABSTRACT: Alzheimer's disease is the most common cause of dementia. A hallmark of this disease is the presence of aberrant deposits containing by the Aβ peptide (amyloid plaques) and the tau protein (neurofibrillary tangles) in the brains of affected individuals. Increasing evidence suggests that the formation of these deposits is closely associated with the age-related dysregulation of a large set of highly expressed and aggregation-prone proteins, which make up a metastable subproteome. To understand in more detail the origins of such dysregulation, we identify specific components of the protein homeostasis system associated with these metastable proteins by using a gene coexpression analysis. Our results reveal the particular importance of the protein trafficking and clearance mechanisms, includi

SUBMITTER: Kundra R 

PROVIDER: S-EPMC5514703 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature