Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.

ABSTRACT: Autoimmune diseases such as systemic lupus erythematosus (SLE) are associated with increased cardiovascular disease and reduced plasma high-density lipoprotein (HDL) levels. HDL mediates cholesterol efflux from immune cells via the ATP binding cassette transporters A1 and G1 (ABCA1/G1). The significance of impaired cholesterol efflux pathways in autoimmunity is unknown. We observed that Abca1/g1-deficient mice develop enlarged lymph nodes (LNs) and glomerulonephritis suggestive of SLE. This lupus-like phenotype was recapitulated in mice with knockouts of Abca1/g1 in dendritic cells (DCs), but not in macrophages or T cells. DC-Abca1/g1 deficiency increased LN and splenic CD11b⁺ DCs, which displayed cholesterol accumulation and inflammasome activation, increased cell surface level

SUBMITTER: Westerterp M 

PROVIDER: S-EPMC5514787 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature