Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages.

ABSTRACT:

Background

The association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation.

Results

Six case-control studies involving 1,781 head and neck cancer patients and 1,978 controls were yielded. The results indicated an association between rs1800896 polymorphism and increased head and neck risk [odds ratio (95%confidence interval) for G vs. A, GA vs. AA, GG vs. AA, GA+GG vs. AA, and GG vs. AA + GA were 1.63 (1.30-2.04), 3.17 (2.11-4.76), 1.63 (1.17-2.26), 1.73 (1.25-2.39), and 2.73 (1.82-4.09), respectively]. The subgroup analyses all obtained similar results with overall population

SUBMITTER: Huang W 

PROVIDER: S-EPMC5514904 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature