Transcriptome profiling reveals miR-9-3p as a novel tumor suppressor in gastric cancer.

ABSTRACT: It has been well established that microRNAs (miRNAs) play important roles in biological processes. To comprehensively measure the altered miRNA expression, we presented the miRNA expression profile of gastric cancer using microarray. We identified 33 miRNAs that were significantly differentially regulated in gastric specimens compared to adjacent normal tissues, among which miR-9-3p expression are significantly down-regulated in gastric cancers. Next, a cohort of 100 gastric cancer tissues and matched normal tissues were enrolled. Kaplan-Meier and multivariate Cox survival analyses were applied to evaluate the prognostic value of miR-9-3p expression, and the result showed that patients with lower miR-9-3p expression level have significantly poorer overall survival. The expression level of

SUBMITTER: Meng Q 

PROVIDER: S-EPMC5514911 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature