Increased risk of brain metastases in women with breast cancer and p16 expression in metastatic lymph-nodes.

ABSTRACT:

Purpose

Metastatic breast cancer is a leading cause of mortality in women, partly on account of brain metastases. However, the mechanisms by which cancer cells cross the blood-brain barrier remain undeciphered. Most molecular studies predicting metastatic risk have been performed on primary breast cancer samples. Here we studied metastatic lymph-nodes from patients with breast cancers to identify markers associated with the occurrence of brain metastases.

Results

Transcriptomic analyses identified CDKN2A/p16 as a gene potentially associated with brain metastases.

Materials and methods

Fifty-two patients with HER2-overexpressing or triple-negative breast carcinoma with lymph nodes and distant metastases were included in this study. Transcriptomic analyses were performe

SUBMITTER: Furet E 

PROVIDER: S-EPMC5514912 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature