Prognostic value of circulating endothelial cells in metastatic colorectal cancer.

ABSTRACT:

Background

There is urgent need for improved staging in patients with metastatic colorectal cancer (mCRC). In this study, we evaluated the prognostic value of circulating endothelial cells (CEC) in comparison with circulating tumor cells (CTC) in patients with mCRC amenable for potentially curative surgery.

Methods

A total of 140 patients were enrolled prospectively. CTC and CEC were measured with the CellSearch System (Veridex, NJ, USA). Cut-off values were determined using ROC analyses. Prognostic factors were identified by Cox proportional hazards models.

Results

ROC analyses revealed ≥ 21 CEC as cut-off levels for detection, which was present in 68 (49%). CEC detection was associated with female gender (p = 0.03) only, whereas CTC detection was associated with pre

SUBMITTER: Rahbari NN 

PROVIDER: S-EPMC5514924 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature