Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies.

ABSTRACT:

Background

Elderly individuals have an eroded immune system but whether immune senescence is implicated with the development of frailty is unknown. The underlying immune mechanisms and the link between markers of senescence and physical frailty is not well established.

Methods

We explored the association of specific T-cell subset markers of immune differentiation and senescence on CD4⁺ and CD8⁺ cells (CD28^-, CD27^- and CD57⁺) and the immune risk profile (inverted CD4/CD8 ratio <1) with physical frailty among 421 participants who were frail (N=32), prefrail (N=187) and robust (N=202) in the Singapore Longitudinal Ageing Study cohort.

Results

In ordinal logistic regression models relating tertile

SUBMITTER: Ng TP 

PROVIDER: S-EPMC5514983 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature