Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.

ABSTRACT:

Background/objectives

Brain-derived neurotrophic factor (BDNF) and its receptor (tropomyosin-related kinase B: TrkB, also known as Ntrk2) have a key role in central regulation of the energy balance. BDNF and TrkB are also expressed in the peripheral tissues, including adipose tissue, but their peripheral role has been unclear. Here we report on the functional significance of the adipose tissue BDNF/TrkB axis in metabolic homeostasis.

Materials and methods

To examine the role of the BDNF/TrkB axis in the central nervous system and in adipose tissue, we generated adipocyte-specific or neuron-specific BDNF/TrkB conditional knockout (CKO) mice. Then we compared the feeding behavior and metabolic profile between each type of CKO mouse and their littermates.

Results

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SUBMITTER: Nakagomi A 

PROVIDER: S-EPMC5514989 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature