Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand.

ABSTRACT:

Introduction

The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. The knowledge gained could inform preventive strategies aimed at reducing VL during AHI and therapeutic strategies to alter the viral kinetics that may enhance the likelihood of achieving HIV remission.

Methods

The analysis utilized VL data captured during the first year of HIV infection from two studies in Thailand: the RV217 study (untreated AHI, 30 participants and 412 visits) and the RV254 study (treated AHI, 235 participants and 2803 visits). Fiebig stages were I/II (HIV RNA+, HIV IgM-) and Fiebig III/IV (HIV IgM+, Western blot-/indetermin

SUBMITTER: Ananworanich J 

PROVIDER: S-EPMC5515031 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature