Time-based measures of treatment effect: reassessment of ticagrelor and clopidogrel from the PLATO trial.

ABSTRACT:

Objective

Treatment effects to binary endpoints using time-to-event data in randomised controlled trials are typically summarised by reporting HRs derived with Cox proportional hazard models. Alternative and complementary methods include summarising the between-treatment differences on the metric time scale, quantifying the effect as delay of the event (DoE). The aim of this study was to reassess data from the PLATO study expressing the effects as the time by which the main outcomes are delayed or hastened due to treatment.

Methods

PLATO was a randomised controlled double-blind multicentre study (n=18,624), conducted between 2006 and 2008, which demonstrated superiority of the antiplatelet treatment ticagrelor over clopidogrel in reducing risk of several cardiovascular event

SUBMITTER: Bellavia A 

PROVIDER: S-EPMC5515127 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature