Breast cancer cell adhesome and degradome interact to drive metastasis.

ABSTRACT:

Background

Although primary breast tumors are detected early in most cases, it is inevitable that many patients remain at risk for future recurrence and death due to micrometastases. We investigated interactions between the degradome and the adhesome that drive metastasis, and have focused on matrix metalloproteases (MMPs) within the degradome and integrins and E-cadherin within the adhesome.

Aims

The aim of this study is to identify interaction networks between adhesion molecules and degradative enzymes in breast cancer metastasis.

Methods

We compared non-metastatic (BT-474, T47D, MCF7) and metastatic (MDA-MB-231, SUM149, SUM159) human breast cancer cell lines and xenografts, in which we measured growth rate, migration, invasion, colony formation, protein expression,

SUBMITTER: Rizwan A 

PROVIDER: S-EPMC5515192 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature