Activin-A signaling promotes epithelial-mesenchymal transition, invasion, and metastatic growth of breast cancer.

ABSTRACT:

Background

Activins belong to the transforming growth factor-β (TGF-β) superfamily of cytokines. Although the role of TGF-β in cancer progression has been highly advocated, the role of activin signaling in cancer is not well known. However, overexpression of activin-A has been observed in several cancers.

Aims

The gene expression profile indicated higher expression of Activin-A in breast tumors. Hence the aim of this study was to evaluate the status and role of Activin signaling pathway in these tumors.

Methods

Microarray analysis was performed to reveal gene expression changes in breast tumors. The results were validated by quantitative PCR and immunohistochemical analysis in two independent sets of normal and tumor samples. Further, correlation of activin expression

SUBMITTER: Bashir M 

PROVIDER: S-EPMC5515205 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature