Anhedonia as a clinical correlate of suicidal thoughts in clinical ketamine trials.

ABSTRACT:

Background

Identifying clinical correlates associated with reduced suicidal ideation may highlight new avenues for the treatment of suicidal thoughts. Anhedonia occurs across psychiatric diagnoses and has been associated with specific neural circuits in response to rapid-acting treatments, such as ketamine. This analysis sought to evaluate whether reductions in suicidal ideation after ketamine administration were related to reduced levels of anhedonia, independent of depressive symptoms.

Methods

This post-hoc analysis included treatment-resistant patients with either major depressive disorder (MDD) or bipolar disorder (BD) from several clinical trials of ketamine. Anhedonia was assessed using a subscale of the Beck Depression Inventory (BDI) and the Snaith-Hamilton Pleasure

SUBMITTER: Ballard ED 

PROVIDER: S-EPMC5515296 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature