Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study.

ABSTRACT:

Background

While some medicinal drugs have been found to affect driving ability, no study has investigated whether a relationship exists between these medicines and crashes involving pedestrians. The aim of this study was to explore the association between the use of medicinal drugs and the risk of being involved in a road traffic crash as a pedestrian.

Methods and findings

Data from 3 French nationwide databases were matched. We used the case-crossover design to control for time-invariant factors by using each case as its own control. To perform multivariable analysis and limit false-positive results, we implemented a bootstrap version of Lasso. To avoid the effect of unmeasured time-varying factors, we varied the length of the washout period from 30 to 119 days before the

SUBMITTER: Nee M 

PROVIDER: S-EPMC5515401 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature