Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study.

ABSTRACT:

Background

Almost all studies that have investigated the immune response to trauma have analysed blood samples acquired post-hospital admission. Thus, we know little of the immune status of patients in the immediate postinjury phase and how this might influence patient outcomes. The objective of this study was therefore to comprehensively assess the ultra-early, within 1-hour, immune response to trauma and perform an exploratory analysis of its relationship with the development of multiple organ dysfunction syndrome (MODS).

Methods and findings

The immune and inflammatory response to trauma was analysed in 89 adult trauma patients (mean age 41 years, range 18-90 years, 75 males) with a mean injury severity score (ISS) of 24 (range 9-66), from whom blood samples were acquired

SUBMITTER: Hazeldine J 

PROVIDER: S-EPMC5515405 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature