Renal function following xenon anesthesia for partial nephrectomy-An explorative analysis of a randomized controlled study.

ABSTRACT:

Background

Perioperative preservation of renal function has a significant impact on morbidity and mortality in kidney surgery. Nephroprotective effects of the anesthetic xenon on ischemia-reperfusion injury were found in several experimental studies.

Objective

We aimed to explore whether xenon anesthesia can reduce renal damage in humans undergoing partial nephrectomy and to gather pilot data of possible nephroprotection in these patients.

Design

A prospective randomized, single-blinded, controlled study.

Setting

Single-center, University Hospital of Aachen, Germany between July 2013-October 2015.

Patients

Forty-six patients with regular renal function undergoing partial nephrectomy.

Interventions

Patients were randomly assigned to receive xenon-

SUBMITTER: Stevanovic A 

PROVIDER: S-EPMC5515428 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature