A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.

ABSTRACT: While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune system to ameliorate disease also carry a risk of immunosuppression that could lead to adverse outcomes. Therefore, it is important to understand the 'immune fingerprint' of novel therapeutics as they relate to current and, clinically used immunological therapies to better understand their potential therapeutic benefit as well as immunosuppressive ability that might lead to adverse events such as infection risks and cancer. Since the mechanistic investigation of pharmacological modulators in a drug discovery setting is largely compound- and mec

SUBMITTER: St Pierre C 

PROVIDER: S-EPMC5515432 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature