<i>UNC5C</i> variants are associated with cerebral amyloid angiopathy.

ABSTRACT:

Objective

To determine whether common genetic variants in UNC5C, a recently identified late-onset Alzheimer disease (LOAD) dementia susceptibility gene, are associated with AD susceptibility or AD-related clinical/pathologic phenotypes.

Methods

We used data from deceased individuals of European descent who participated in the Religious Orders Study or the Rush Memory and Aging Project (n = 1,288). We examined whether there were associations between single nucleotide polymorphisms (SNPs) within ±100 kb of the UNC5C gene and a diagnosis of AD dementia, global cognitive decline, a pathologic diagnosis of AD, β-amyloid load, neuritic plaque count, diffuse plaque count, paired helical filament tau density, neurofibrillary tangle count, and cerebral amyloid angiopath

SUBMITTER: Yang HS 

PROVIDER: S-EPMC5515600 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature