Potential impact on HIV incidence of higher HIV testing rates and earlier antiretroviral therapy initiation in MSM.

ABSTRACT:

Background

Increased rates of testing, with early antiretroviral therapy (ART) initiation, represent a key potential HIV-prevention approach. Currently, in MSM in the United Kingdom, it is estimated that 36% are diagnosed by 1 year from infection, and the ART initiation threshold is at CD4 cell count 350/μl. We investigated what would be required to reduce HIV incidence in MSM to below 1 per 1000 person-years (i.e. <535 new infections per year) by 2030, and whether this is likely to be cost-effective.

Methods

A dynamic, individual-based simulation model was calibrated to multiple data sources on HIV in MSM in the United Kingdom. Outcomes were projected according to future alternative HIV testing and ART initiation scenarios to 2030, considering also potential changes in leve

SUBMITTER: Phillips AN 

PROVIDER: S-EPMC5515630 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature