Effect of CXCL12/CXCR4 signaling on neuropathic pain after chronic compression of dorsal root ganglion.

ABSTRACT: Neuropathic pain is a complex, chronic pain state that often accompanies tissue damage, inflammation or injury of the nervous system. However the underlying molecular mechanisms still remain unclear. Here, we showed that CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of DRG (CCD), and some CXCR4 immunopositive neurons were also immunopositive for the nociceptive neuronal markers IB4, TRPV1, CGRP, and substance P. The incidence and amplitude of CXCL12-induced Ca²⁺ response in primary sensory neurons from CCD mice was significantly increased compared to those from control animals. CXCL12 depolarized the resting membrane potential, decreased the rheobase, and increased the number of action potentials evoked by a depolarizing current at

SUBMITTER: Yu Y 

PROVIDER: S-EPMC5515923 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature