Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells.

ABSTRACT: Tuberculosis (TB) is a deadly infectious disease, which kills millions of people every year. The causative pathogen, Mycobacterium tuberculosis (MTB), is estimated to have infected up to a third of the world's population; however, only approximately 10% of infected healthy individuals progress to active TB. Despite evidence for heritability, it is not currently possible to predict who may develop TB. To explore approaches to classify susceptibility to TB, we infected with MTB dendritic cells (DCs) from putatively resistant individuals diagnosed with latent TB, and from susceptible individuals that had recovered from active TB. We measured gene expression levels in infected and non-infected cells and found hundreds of differentially expressed genes between susceptible and resistant individu

SUBMITTER: Blischak JD 

PROVIDER: S-EPMC5516010 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature