Pattern of retinal morphological and functional decay in a light-inducible, rhodopsin mutant mouse.

ABSTRACT: Hallmarks of Retinitis Pigmentosa (RP), a family of genetic diseases, are a typical rod-cone-degeneration with initial night blindness and loss of peripheral vision, followed by decreased daylight sight and progressive visual acuity loss up to legal blindness. Great heterogeneity in nature and function of mutated genes, variety of mutations for each of them, variability in phenotypic appearance and transmission modality contribute to make RP a still incurable disease. Translational research relies on appropriate animal models mimicking the genetic and phenotypic diversity of the human pathology. Here, we provide a systematic, morphological and functional analysis of Rho^Tvrm4/Rho⁺ rhodopsin mutant mice, originally described in 2010 and portraying several features of co

SUBMITTER: Gargini C 

PROVIDER: S-EPMC5516022 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature