Olfactory bulb plasticity ensures proper olfaction after severe impairment in postnatal neurogenesis.

ABSTRACT: The olfactory bulb (OB) neurons establish a complex network that ensures the correct processing of the olfactory inputs. Moreover, the OB presents a lifelong addition of new neurons into its existing circuitry. This neurogenesis is considered essential for the OB function. However, its functional impact on physiology and behavior is still unclear. Here, we investigate the mechanisms of OB plasticity that underlie bulbar physiology in relation to severe damage of neurogenesis. The neurogenesis of young mice was altered by ionizing radiation. Afterwards, both multi-channel olfactometry and electrophysiological studies were performed. Furthermore, neurogenesis and differentiation of the newly formed cells were assessed using bromodeoxyuridine labeling combined with a wide battery of neuronal

SUBMITTER: Diaz D 

PROVIDER: S-EPMC5516035 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature